Dr. Wangler's research interests include the brain's plasticity and response to injury such as stroke. Specifically, her interest is in neurolysin's role in post-ischemic injury and has dedicated several years in its study. She earned her undergraduate degree from West Texas A&M University where she majored in biology, and her PhD in pharmaceutical sciences with anemphasis in physiology-based pharmacology from Texas Tech Graduate School of Biomedical Sciences.
Courses taught:
Integrated Human Anatomy and Physiology A Laboratory (HLTH 301)
Integrated Human Anatomy and Physiology B Laboratory (HLTH 302)
Human Form and Function (HLTH 195)
The Physiology and Social Impacts of Drug Abuse (HLTH 380-304)
Publications:
Jayaraman S, Al Shoyaib A, Kocot J, Villaba H, Alamri FF, Rashid M, Wangler NJ, et al., Peptidase neurolysin functions to preserve the brain after ischemic stroke in male mice. Journal of Neurochemistry. 2020 Apr; 153(1): 120-137.
Rashid M, Wangler NJ, Yang L, Shah K, Arumugam TV, Abbruscato TJ, Karamyan VT. Functional up-regulation of endopeptidase neurolysin during post-acute and early recovery phases of experimental stroke in mouse brain. Journal of Neurochemistry. 2014 Apr; 129(1): 179-89.
Wangler NJ, et al., Preparation and preliminary characterization of recombinant neurolysin for in vivo studies. Journal of Biotechnology, 22016. 34:105-15.
Wangler NJ, et al., Identification of membrane-bound varient of metalloendopeptidase neurolysin (EC 3.4.24.16) as the non-angiotensin type 1 (non-AT1), non-AT2 angiotensin binding site. Journal of Biological Chemistry, 2012. 287 (1): p. 114-122.