Classes Taught
- General Chemistry
- Biochemistry
- Advanced Topics in Protein Biochemistry
Dr. Jin's research has focused on the study of biomolecular interactions using Isothermal Titration Calorimetry (ITC). ITC directly measures the heat associated with most biomolecular interactions to determine thermodynamic parameters including binding affinity, stoichiometry, and binding energetics to lead us to a better understanding of molecular interactions. Systems studied so far include the interactions of proteins, peptides, antibiotics, amino acids, drugs and drug candidates with small molecules and metal ions. Such studies also contribute to better drug designs and testing.
Selected Publications
- Robinson, S.G., Burns, P.T., Miceli, A.M., Grice, K.A., Karver, C.E., and Jin, L*. (2016) “Calorimetric Studies of the Interaction of Metalloenzyme Active Site Mimetics with Zinc-binding Inhibitors”, Dalton Transactions 45, 11817 – 11829.
- Arias, K, Robinson, S.G., Lyngaas, S. S., Cherala, S. S., Hartzell, M., Mei, S., Vilic, A., Girel, J. K., Kuemmell, A., Vrettos, J. S., Zielinski, J., Liechti, K., Jin, L*. (2016) “Minocycline and Tigecycline Form Higher-Order Ca2+ Complexes of Stronger Affinity than Tetracycline”, Inorg. Chim. Acta. 441, 181-191.
- Jin, L., Sakiyan, I., Gonzales, N. S., Lane, D., and Cherala, S. S. (2014) “Synthesis, Characterization and Cu2+ Binding Studies of L-Histidine Ester of 8-Hydroxyquinoline” Inorg. Chim. Acta. 423, 72-78.
- Strawn, R., Stockner, T., Melichercik, M., Jin, L., Xue, W. F., Carey, J., Ettrich, R. “Synergy of molecular dynamics and isothermal titration calorimetry in studies of allostery” Methods in Enzymology (2011) 492 , 151-188.
- Jin, L., Amaya-Mazo, X., Apel, M. E., Sankisa, S. S.; Johnson, E., Zbyszynska, M. A., Han, A. (2007) “Ca2+ and Mg2+ bind tetracycline with distinct stoichiometries and linked deprotonation” Biophysical Chemistry 128(2-3), 185-196.